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Anti -BLNK Rabbit pAb For IHC IF

Specification:100uL
  • GB11734
  • Servicebio
  • Servicebio

Description

Product Information


Description

BLNK rabbit polyclonal

Protein full name

B-cell linker protein

Synonyms

Blnk, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, Bca, B-cell linker

Immunogen

Recombinant protein corresponding to Mouse BLNK

Isotype

IgG

Purity

Affinity purification

Subcellular location

Membrane

Uniprot ID

Q9QUN3, Q4KM52




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 3000-1: 5000

spleen

IF

Mouse, Rat

1: 1500-1: 2500

spleen




Background


The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using

BLNK (GB11734) at dilution of 1: 3000


image.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using

BLNK (GB11734) at dilution of 1: 3000





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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