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Anti -Glutamine Synthetase Rabbit pAb

  • Servicebio

Description

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Product Information

Description

Glutamine Synthetase rabbit polyclonal

Protein full name

Glutamine synthetase

Synonyms

Cell proliferation-inducing protein 59, GLNA, GLNS, GLUL,Glutamate ammonia ligase, Glutamate decarboxylase, Glutamine synthetase, GS, PIG43, PIG59,Proliferation inducing protein 43

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Glutamine Synthetase

Isotype

IgG

Purity

Affinity purification

Predicted MW.

42 kDa

Observed MW.

42 kDa

Uniprot ID

P15104, P15105, P09606



Applications

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1500

liver, lung, kidney



Background

Glutamine Synthetase catalyzes the conversion of ammonia and glutamate to glutamine. The function of Glutamine Synthetase is the detoxification of brain ammonia. It also has an important role in the metabolic regulation of neurotransmitter glutamate. Because of the multiple functions and importance of Glutamine Synthetase in cellular metabolism, both catalytic activities and synthesis are highly regulated. The activity of Glutamine Synthetase is controlled by adenylylation. Its activity is decreased in the cerebral cortex of brains affected by Alzheimer's disease, particularly in the vicinity of senile plaques. It is also decreased under conditions of glucose deprivation. The level of expression of Glutamine Synthetase is increased during ischemia in vivo or hypoxia in culture.


Images

image.png

Western blot analysis of Glutamine Synthetase (GB11736) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: MCF7 cell lysate

Lane 3: Jurkat cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse lung tissue lysate

Lane 6: Mouse kidney tissue lysate

Lane 7: Rat liver tissue lysate

Lane 8: Rat lung tissue lysate

Lane 9: Rat kidney tissue lysate


Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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