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Anti -BCAR1 Rabbit pAb Western Blot Antibodies

Specification: 100uL
  • GB11738
  • Servicebio
  • Servicebio

Description

Product Information


Description

BCAR1 rabbit polyclonal

Protein full name

Breast cancer anti-estrogen resistance protein 1

Synonyms

Bcar1, BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas, Cas family scaffolding protein, Cas family scaffold protein

Immunogen

Recombinant protein corresponding to Mouse BCAR1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

95 kDa

Observed MW.

95 kDa

Uniprot ID

P56945, Q61140, Q63767




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

testis, uterus, brain




Background


BCAR1 is a ubiquitously expressed adaptor molecule originally identified as the major substrate of v-Src and v-Crk . p130Cas/BCAR1 belongs to the Cas family of adaptor proteins and can act as a docking protein for several signalling partners. Due to its ability to associate with multiple signaling partners, p130Cas/BCAR1 contributes to the regulation to a variety of signaling pathways leading to cell adhesion, migration, invasion, apoptosis, hypoxia and mechanical forces. p130Cas/BCAR1 plays a role in cell transformation and cancer progression and alterations of p130Cas/BCAR1 expression and the resulting activation of selective signalling are determinants for the occurrence of different types of human tumors.




Images



image.png

Western blot analysis of BCAR1

(GB11738 ) at dilution of 1: 1000

Lane 1: HepG2 cell lysate

Lane 2: Raw264.7 cell lysate

Lane 3: Mouse testis tissue lysate

Lane 4: Mouse uterus tissue lysate

Lane 5: Mouse brain tissue lysate

Lane 6: Rat testis tissue lysate

Lane 7: Rat testis tissue lysate

Lane 8: Rat uterus tissue lysate

Lane 9: Rat brain tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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