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Anti -IOP2 Rabbit PAb IHC IF Primary Antibody

Specification: 100uL
  • GB11748
  • Servicebio
  • Servicebio

Description

Product Information


Description

IOP2 rabbit polyclonal

Protein full name

Nuclear prelamin A recognition factor

Synonyms

Narf, NARF, IOP2, Nuclear prelamin A recognition factor, Iron only hydrogenase like protein 2

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse IOP2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

Q9CYQ7, Q2YDU6




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 2000-1: 3000

lung, pancreas

IF

Mouse, Rat

1: 1000-1: 1500

lung, pancreas




Background


Renylation was initially believed to be important only for membrane attachment. However, another role for prenylation appears to be its importance in protein–protein interactions. The only nuclear proteins known to be prenylated in mammalian cells are prelamin A- and B-type lamins. Prelamin A is farnesylated and carboxymethylated on the cysteine residue of a carboxyl-terminal CaaX motif. This post-translationally modified cysteine residue is removed from prelamin A when it is endoproteolytically processed into mature lamin A. The encoded protein binds to the prenylated prelamin A carboxyl-terminal tail domain. It may be a component of a prelamin A endoprotease complex. The encoded protein is located in the nucleus, where it partially colocalizes with the nuclear lamina. It shares limited sequence similarity with iron-only bacterial hydrogenases.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using

IOP2 (GB11748) at dilution of 1: 2000


image.png

Immunohistochemistry analysis of paraffin-embedded rat lung using

IOP2 (GB11748) at dilution of 1: 2000


image.png

Immunohistochemistry analysis of paraffin-embedded rat pancreas using

IOP2 (GB11748) at dilution of 1: 2000





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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