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Anti -CrkL Rabbit PAb for Western Blot Polyclonal Antibody

Specification: 100uL
  • GB11756
  • Servicebio
  • Servicebio

Description

Product Information  


Description

CrkL rabbit polyclonal

Protein full name

Crk-like protein

Synonyms

Crkl, CRKL, CRK like proto-oncogene, Adaptor protein

Immunogen

Recombinant protein corresponding to Mouse CrkL

Isotype

IgG

Purity

Affinity purification

Predicted MW.

34 kDa

Observed MW.

39 kDa

Uniprot ID

P46109, P47941, Q5U2U2




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

HT29, Jurkat,

HepG2, brain




Background


V-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. Crk-like protein encoded by the CRKL gene, has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.




Images



image.png

Western blot analysis of CrkL (GB11756)

at dilution of 1: 1000

Lane 1: HT29 cell lysate

Lane 2: Jurkat cell lysate

Lane 3: HepG2 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Rat brain tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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