Substance-K receptor is a protein encoded by the TACR2 gene. This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neuropeptide substance K, also referred to as neurokinin A. The rank order of affinity of this receptor to tachykinins is: substance K > neuromedin-K > substance P.
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