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Anti -Caspase-3 Rabbit PAb for Western Blot Polyclonal Antibody

Specification: 100uL
  • GB11767C
  • Servicebio
  • Servicebio

Description

Product Information



Description

Caspase-3 rabbit polyclonal

Protein full name

Caspase-3

Synonyms

Casp3, CASP3, CPP32, CPP32B, SCA-1, caspase 3

Immunogen

Recombinant protein corresponding to

Mouse Caspase-3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

32 kDa

Observed MW.

35 kDa

Uniprot ID

P70677, Q8MJC3 




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

liver, lung, brain




Background


Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes.




Images


Western blot analysis of Caspase-3 (GB11767C) at dilution of 1: 1000

Lane 1: NIH/3T3 cell lysate

Lane 2: Mouse liver tissue lysate

Lane 3: Mouse lung tissue lysate

Lane 4: Rat brain tissue lysate

Lane 5: Rat liver tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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