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Anti -PI 3 Kinase catalytic subunit alpha/PIK3CA Rabbit pAb IHC immunofluorescence Primary antibody

Specification: 100uL
  • GB11769
  • Servicebio
  • Servicebio

Description

Product Information


Description

PIK3CA rabbit polyclonal

Protein full name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Synonyms

PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha, PI3K-alpha, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha, CLAPO

Immunogen

Recombinant protein corresponding to Mouse PIK3CA

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Cell membrane

Uniprot ID

P42337




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 1000-1: 2000

brain, hippocampus

IF

Mouse, Rat

1: 500-1: 1000

brain, hippocampus




Background


PI3-Kinases (PI3-Ks) are a family of lipid kinases that are implicated in signal transduction. Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The p85 subunit localize PI3-K activity to the plasma membrane while the p110 subunit contains the catalytic domain of PI3-K which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdInsP2. Four isoforms of p110 has been found; alpha, beta, gamma, and the delta subunit. The alpha isoform, also known as PI3KCA, is a transforming oncogene that was shown to have activating mutations in nine types of cancers such as colon, brain, breast and stomach.




Images



image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using

PIK3CA (GB11769) at dilution of 1: 1000


image.png

Immunohistochemistry analysis of paraffin-embedded rat hippocampus using PIK3CA (GB11769) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using

PIK3CA (GB11769) at dilution of 1: 1000





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.


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