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Anti -Bcl10 Rabbit PAb for IHC IF Apoptosis Detection Antibody

Specification: 100uL
  • GB11771
  • Servicebio
  • Servicebio

Description

Product Information


Description

Bcl10 rabbit polyclonal

Protein full name B-cell lymphoma/leukemia 10

Synonyms

Bcl10, BCL10, CARMEN, CIPER, CLAP, c-E10, mE10, IMD37, B-cell CLL/lymphoma 10, B cell CLL/lymphoma 10, immune signaling adaptor, BCL10 immune signaling adaptor

Immunogen

Recombinant protein corresponding to Mouse Bcl10

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm

Uniprot ID

Q9Z0H7, Q9QYN5




Applications



Applications

IHC

IF

Species

Mouse, Rat

Mouse, Rat

Dilution

1: 500-1: 1000

1: 250-1: 500

Positive tissue

brain, spleen

brain, spleen




Background




B-cell lymphoma/leukemia 10 contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and pro-caspase-9 maturation and to activate NF-kappaB via NIK and IKK. The protein may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. It is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with the paracaspase MALT1. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.




Images



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Immunohistochemistry analysis of paraffin-embedded mouse brain using Bcl10 (GB11771) at dilution of 1: 800

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Immunohistochemistry analysis of paraffin-embedded mouse spleen using Bcl10 (GB11771) at dilution of 1: 800

image.png

Immunohistochemistry analysis of paraffin-embedded rat spleen using Bcl10 (GB11771) at dilution of 1: 800




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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