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Anti -NBR1 Rabbit pAb Immunohistochemistry immunofluorescence Primary antibody

Specification: 100uL
  • GB11788
  • Servicebio
  • Servicebio

Description

Product Information



Description

NBR1 rabbit polyclonal

Protein full name

Next to BRCA1 gene 1 protein

Synonyms

Nbr1, NBR1, 1A1-3B, IAI3B, M17S2, MIG19, neighbor of BRCA1 gene 1, autophagy cargo receptor, NBR1 autophagy cargo receptor

Immunogen

Recombinant protein corresponding to Mouse NBR1

Isotype IgG
Purity Affinity purification
Subcellular location

Cytoplasm

Uniprot ID

Q14596




Applications



Applications

IHC

IF

Species

Human

Human

Dilution

1: 500-1: 1000

1: 250-1: 500

Positive tissue

lung cancer,colon cancer,stomach cancer

lung cancer,colon cancer,stomach cancer




Background




Neighbor of BRCA1 gene 1 protein is a protein encoded by the NBR1 gene. The protein  was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.[6] One implied function lies in autophagy, where it acts a cargo receptor in selective autophagy.




Images



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Immunohistochemistry analysis of paraffin-embedded human lung cancer using NBR1 (GB11788) at dilution of 1: 1000

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Immunohistochemistry analysis of paraffin-embedded human colon cancer using NBR1 (GB11788) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded human stomach cancer using NBR1 (GB11788) at dilution of 1: 1000




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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