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Anti -Syk Rabbit PAb for Western Blot Polyclonal Antibody

Specification: 100uL
  • GB11789
  • Servicebio
  • Servicebio

Description

Product Information


Description Syk rabbit polyclonal
Protein full name Tyrosine-protein kinase SYK
Synonyms Syk, SYK, p72-Syk, spleen tyrosine kinase, spleen associated tyrosine kinase
Immunogen Recombinant protein corresponding to
Mouse Syk
Isotype IgG
Purity Affinity purification
Predicted MW. 72 kDa
Observed MW. 75 kDa
Uniprot ID P43405, P48025, Q64725




Applications


Applications Species Dilution Positive Tissue
WB Human, Mouse, Rat 1: 500-1: 1000 spleen, lung,
lymph gland




Background



Spleen tyrosine kinase, also known as Syk, is an enzyme encoded by the SYK gene. SYK, along with Zap-70, is a member of the Syk family of tyrosine kinases. These non-receptor cytoplasmic tyrosine kinases share a characteristic dual SH2 domain separated by a linker domain. However, activation of SYK relies less on phosphorylation by Src family kinases than Zap-70. While Syk and Zap-70 are primarily expressed in hematopoietic tissues, there is expression of Syk in a variety of tissues. Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins.




Images



image.png

Western blot analysis of Syk (GB11789) at dilution of 1: 800

Lane 1: Jurkat cell lysate

Lane 2: K562 cell lysate

Lane 3: THP-1 cell lysate

Lane 4: Mouse spleen tissue lysate

Lane 5: Mouse lung tissue lysate

Lane 6: Mouse lymph gland tissue lysate

Lane 7: Rat lung tissue lysate

Lane 8: Rat lymph gland tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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