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Anti -FAM123B Rabbit pAb for WB Protein detection

Specification: 100uL
  • GB11816
  • Servicebio
  • Servicebio

Description

Product Information



Description

FAM123B rabbit polyclonal

Protein full name

APC membrane recruitment protein 1

Synonyms

Amer1, AMER1, wtx, OSCS, Wilms tumor gene on the X chromosome protein, Wilms tumor on the X, WTX

Immunogen

Recombinant protein corresponding to Mouse FAM123B

Isotype IgG
Purity Affinity purification

Predicted MW.

125 kDa

Observed MW.

125 kDa

Uniprot ID

Q5JTC6Q7TS75




Applications



Applications

WB

Species

Human, Mouse, Rat

Dilution

1: 500-1: 1000

Positive tissue

kidney, brain, lung




Background



Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context: acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta-catenin destruction complex and promoting stabilization of Axin at the cell membrane. Promotes CTNNB1 ubiquitination and degradation. Involved in kidney development.

         



Images



image.png

Western blot analysis of FAM123B (GB11816) at dilution of 1: 1000

Lane 1: Mouse kidney tissue lysate

Lane 2: Mouse brain tissue lysate

Lane 3: Mouse lung tissue lysate

Lane 4: Rat kidney tissue lysate

Lane 5: Rat brain tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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