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Anti -Wnt1 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

Wnt1 rabbit polyclonal

Protein full name

Proto-oncogene Wnt-1

Synonyms

Wnt1, WNT1, BMND16, INT1, OI15, Wnt family member 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Wnt1

Isotype IgG
Purity Affinity purification
Subcellular location

Secreted

Uniprot ID

P04628, P04426


Applications

Applications

IHC

IF

Species

Human, Mouse, Rat

Human, Mouse, Rat

Dilution

1:1500-1: 3000

1: 750-1: 1500

Positive tissue

stomach cancer, spleen, brain

stomach cancer, spleen, brain


Background

Proto-oncogene protein Wnt-1 is a protein encoded by the WNT1 gene. The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. The studies in mouse indicate that the Wnt1 protein functions in the induction of the mesencephalon and cerebellum. This gene was originally considered as a candidate gene for Joubert syndrome, an autosomal recessive disorder with cerebellar hypoplasia as a leading feature. However, further studies suggested that the gene mutations might not have a significant role in Joubert syndrome.


Images

image.png

Immunohistochemistry analysis of paraffin-embedded human stomach cancer using Wnt1 (GB11822) at dilution of 1: 1500

image.png

Immunohistochemistry analysis of paraffin-embedded mouse spleen using Wnt1 (GB11822) at dilution of 1: 1500

image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using Wnt1 (GB11822) at dilution of 1: 1500


Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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