βTrCP2 (beta-transducin repeat containing protein 2; also known as Fbxw11 or HOS) is a protein encoded by the FBXW11 gene. The protein is a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation -dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbws class and in addition to an F-box, contains multiple WD40 repeats.
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