Paxillin is a protein encoded by the PXN gene. Paxillin is a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Mutations in PXN as well as abnormal expression of paxillin protein has been implicated in the progression of various cancers. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties.
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