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Anti -Cytokeratin 6a Rabbit pAb

  • Servicebio

Description

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Product Information

Description

Cytokeratin 6a rabbit polyclonal

Protein full name

Keratin, type II cytoskeletal 6A

Synonyms

Krt6a, Keratin 6A, CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D, PC3, CK-6C, CK-6E, Keratin 6A, Cytokeratin 6a

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Cytokeratin 6a

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoskeleton

Uniprot ID

P50446



Applications

Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 500-1: 1000

epityphlon, skin, stomach

IF

Mouse, Rat

1: 250-1: 500

epityphlon, skin, stomach



Background

Keratin 6A (protein name K6A; gene name KRT6A) is a type II cytokeratin, one of a number of isoforms of keratin 6 encoded by separate genes located within the type II keratin gene cluster on human chromosome 12q. It is found with keratin 16 and/or keratin 17 in the palm and sole epidermis, the epithelial cells of the nail bed, the filiform papillae of the tongue, the epithelial lining of oral mucosa and esophagus, as well as the hair follicles. This keratin 6 isoform is thought to be the most abundant of the K6 isoforms. Mutations in the genes expressing this protein is associated with the PC-K6A subtype of pachyonychia congenita, an inherited disorder of the epithelial tissues in which keratin 6A is expressed, particularly leading to structural abnormalities of the nails, the epidermis of the palms and soles, and oral epithelia.


Images

image.png

Immunohistochemistry analysis of paraffin-embedded human epityphlon using

Cytokeratin 6a (GB11838) at dilution of 1: 800


image.png

Immunohistochemistry analysis of paraffin-embedded rat skin using

Cytokeratin 6a (GB11838) at dilution of 1: 800


image.png

Immunohistochemistry analysis of paraffin-embedded mouse stomach using

Cytokeratin 6a (GB11838) at dilution of 1: 800



Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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