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Anti -ATG3 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

ATG3 rabbit polyclonal

Protein full name

Ubiquitin-like-conjugating enzyme ATG3

Synonyms

Autophagy-related protein 3, Protein PC3-96, APG3-like, hApg3, ATG3, APG3, APG3L

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse ATG3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

36 kDa

Observed MW.

40 kDa

Uniprot ID

Q9CPX6, Q6AZ50



Applications

Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

muscle



Background

E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.


Images

image.png

Western blot analysis of ATG3

(GB11839) at dilution of 1: 1000

Lane 1: Mouse muscle tissue lysate

Lane 2: Rat muscle tissue lysate


Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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