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Anti -JNK3 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

JNK3 rabbit polyclonal

Protein full name

Mitogen-activated protein kinase 10

Synonyms

JNK3, MAPK10, JNK3A, PRKM10, SAPK1b, Mitogen-activated protein kinase 10

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse JNK3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

53 kDa

Observed MW.

53 kDa

Uniprot ID

Q61831, P53779, P49187



Applications

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

brain, cerebellum,

spinal cord



Background

MAPK10 (JNK3) is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuron-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways of neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 (CDK5) can phosphorylate and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis.


Images

image.png

Western blot analysis of JNK3

(GB11846) at dilution of 1: 1000

Lane 1: 293T cell lysate

Lane 2: HeLa cell lysate

Lane 3: U87 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Mouse cerebellum tissue lysate

Lane 6: Mouse spinal cord tissue lysate

Lane 7: Rat brain tissue lysate

Lane 8: Rat cerebellum tissue lysate

Lane 9: Rat spinal cord tissue lysate



Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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