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Anti -keap1 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

keap1 rabbit polyclonal

Protein full name

Kelch-like ECH-associated protein 1

Synonyms

keap1, INrf2, KLHL19, Kelch like ECH associated protein 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse keap1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Uniprot ID

Q9Z2X8, Q14145, P57790



Applications

Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 1500-1: 3000

colon, uterus,

small intestine

IF

Human, Mouse, Rat

1: 750-1: 1500

colon, uterus,

small intestine



Background

Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress. Under quiescent conditions, Nrf2 is anchored in the cytoplasm through binding to Keap1, which in turn facilitates the ubiquitination and subsequent proteolysis of Nrf2. Such sequestration and further degradation of Nrf2 in the cytoplasm are mechanisms for the repressive effects of Keap1 on Nrf2.


Images

image.png

Immunohistochemistry analysis of paraffin-embedded human colon using

keap1 (GB11847) at dilution of 1: 1500


image.png

Immunohistochemistry analysis of paraffin-embedded mouse colon using

keap1 (GB11847) at dilution of 1: 1500


image.png

Immunohistochemistry analysis of paraffin-embedded rat small intestine using

keap1 (GB11847) at dilution of 1: 1500


image.png

Immunohistochemistry analysis of paraffin-embedded mouse uterus using

keap1 (GB11847) at dilution of 1: 1500




Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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