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Anti -LOXL2 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

LOXL2 rabbit polyclonal

Protein full name

Lysyl oxidase homolog 2

Synonyms

LOXL2, LOR2, WS9-14, lysyl oxidase like 2, LOR

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse LOXL2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

87 kDa

Observed MW.

87 kDa

Uniprot ID

Q9Y4K0



Applications

Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

HeLa, Lncap, 293T,

A431, NIH/3T3, U87



Background

Lysyl oxidase homolog 2 is an enzyme encoded by the LOXL2 gene. This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. LOXL2 can also crosslink collagen type IV and hence influence the sprouting of new blood vessels.


Images

image.png

Western blot analysis of LOXL2

(GB11849) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: Lncap cell lysate

Lane 3: 293T cell lysate

Lane 4: A431 cell lysate

Lane 5: NIH/3T3 cell lysate

Lane 6: U87 cell lysate



Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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