PHONE

+86(027) 5111 3188

Share to:

Anti -MSK1 Rabbit pAb

  • Servicebio

Description

Download Attachment Files
Attachment Download Address: ×
/e/DownSys/DownSoft/?classid=285&id=5215&pathid=0

Product Information

Description

MSK1 rabbit polyclonal

Protein full name

Ribosomal protein S6 kinase alpha-5

Synonyms

Rps6ka5, RPS6KA5, MSK1, MSPK1, RLPK, Ribosomal protein S6 kinase A5, Mitogen and stress activated protein kinase 1

Immunogen

Recombinant protein corresponding to Mouse MSK1

Isotype

IgG

Purity

Affinity purification

Predicted MW.

90 kDa

Observed MW.

90 kDa

Uniprot ID

O75582, Q8C050



Applications

Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

brain, lung, thymus



Background

Ribosomal protein S6 kinase alpha-5 is an enzyme encoded by the RPS6KA5 gene. MSK1 is a mitogen and stress activated protein kinase 1 which belongs to the AGC family of kinases and is related in structure to the ribosomal p70 S6 kinase subfamily. MSK1 can be activated by ERK1/2 and SAPK2/p38 MAP kinase. It is also known to be required for the phosphorylation of CREB, ATF1 H3 and HMG14 in response to mitogen and stress. Similar to RSK, MSK1 contains two kinase domains (N term and a C term). Once phosphorylated on Thr581 and Ser360 by ERK1/2 and SAPK2/p38, MSK1 autophosphorylate on at least 5 sites. Of these autophosphorylation sites Ser212 and Ser376 get phosphorylated by the C terminal kinase domain of MSK1 which is essential for the catalytic activity of the N terminal kinase domain.


Images

image.png

Western blot analysis of MSK1

(GB11857) at dilution of 1: 1000

Lane 1: SKBR3 cell lysate

Lane 2: 293T cell lysate

Lane 3: L929 cell lysate

Lane 4: Mouse brain tissue lysate

Lane 5: Mouse lung tissue lysate

Lane 6: Mouse thymus tissue lysate

Lane 7: Rat brain tissue lysate

Lane 8: Rat lung tissue lysate

Lane 9: Rat thymus tissue lysate



Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

Contact us

Quick Links

Product Category

Get In Touch

 5th Floor, 22 Building, Biopark, Gaoxin 2nd Road No. 388, East Lake High-Tech Developing Zone, Wuhan, Hubei, China 430079
 +86(027) 5111 3188
Copyright © 2021  Wuhan Servicebio Technology Co., Ltd.