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Anti -PLSCR3 Rabbit pAb

  • Servicebio

Description

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Product Information

Description

PLSCR3 rabbit polyclonal

Protein full name

Phospholipid scramblase 3

Synonyms

Plscr3, PLSCR3, phospholipid scramblase 3, Ca(2+)-dependent phospholipid scramblase 3, phospholipid

Immunogen

Recombinant protein corresponding to Mouse PLSCR3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

32 kDa

Observed MW.

32 kDa

Uniprot ID

Q9JIZ9, Q6QBQ4



Applications

Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

lung, uterus, brain



Background


PLSCR3 (phospholipid scramblase 3) may mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system. Members of this family, PLS1 and PLS3 are both substrates of Protein kinase C (PKC) delta and are phosphorylated by PKC-delta during apoptosis. PKC-delta translocates to mitochondria during apoptosis and phosphorylates PLS3. Overexpression of PLS3 in the HEK293 cells enhanced apoptosis induced by UV-irradiation.


Images

image.png

Western blot analysis of PLSCR3

(GB11859) at dilution of 1: 1000

Lane 1: Mouse lung tissue lysate

Lane 2: Mouse uterus tissue lysate

Lane 3: Rat brain tissue lysate

Lane 4: Rat lung tissue lysate

Lane 5: Rat uterus tissue lysate



Storage

Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.


NOTE: This product is intended for research only.

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