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GB11885 Anti -Tal1 Rabbit pAb Anitbody

Immunogen: Recombinant protein corresponding to Mouse Tal1
Isotype: IgG
Purity: Affinity purification

 

ul:
  • GB11885
  • Servicebio

Description

Product Information


Description

Tal1 rabbit polyclonal

Protein full name

T-cell acute lymphocytic leukemia protein 1 homolog

Synonyms

Tal1, TAL1, SCL, TCL5, bHLHa17, tal-1, T-cell acute lymphocytic leukemia 1, TAL bHLH transcription factor 1, erythroid differentiation factor

Immunogen

Recombinant protein corresponding to

Mouse Tal1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P22091




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 800-1: 1500

hepatitis, spleen

IF

Rat

1: 400-1: 1000

hepatitis, spleen




Background


Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase alpha, a serine/ threonine protein kinase known to modulate the activity of other bHLH transcription factors.




Images


Immunohistochemistry analysis of paraffin-embedded rat hepatitis using

Tal1 (GB11885) at dilution of 1: 1500


Immunohistochemistry analysis of paraffin-embedded rat spleen using

Tal1 (GB11885) at dilution of 1: 1500







Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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