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GB11894 Anti -MEK5 Rabbit pAb Antibody for Western Blot

Immunogen: Recombinant protein corresponding to Mouse MEK5
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11894
  • Servicebio

Description

Product Information


Description

MEK5 rabbit polyclonal

Protein full name

Dual specificity mitogen-activated protein kinase kinase 5

Synonyms

Map2k5, MAP2K5, HsT17454, MAPKK5, MEK5, PRKMK5, Mitogen-activated protein kinase kinase 5

Immunogen

Recombinant protein corresponding to Mouse MEK5

Isotype

IgG

Purity

Affinity purification

Predicted MW.

50 kDa

Observed MW.

50 kDa

Uniprot ID

Q13163, Q9WVS7, Q62862




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

lung, spinal cord,

heart, skeletal muscle




Background


MEK5 is a dual specificity protein kinase belonging to thr Ser/Thr protein kinase family, (MAP kinase kinase family). It is activated by phosphorylation on Ser/Thr by MAP kinase kinases and interacts specifically with ERK5, and not with another MAP kinase like P38. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). It is not phosphorylated by RAFA, RAFB or RAFC and it may interact with GTPases such as CDC42. The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. MEK5 is expressed in many adult tissues and is most abundant in heart and skeletal muscle.




Images



image.png

Western blot analysis of MEK5

(GB11894) at dilution of 1: 1000

Lane 1: U251 cell lysate

Lane 2: Mouse lung tissue lysate

Lane 3: Mouse heart tissue lysate

Lane 4: Mouse spinal cord tissue lysate

Lane 5: Mouse skeletal muscle tissue lysate

Lane 6: Rat lung tissue lysate

Lane 7: Rat heart tissue lysate

Lane 8: Rat spinal cord tissue lysate

Lane 9: Rat skeletal muscle tissue lysate





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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