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GB11899 Anti -AMPK beta 1 Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse AMPKβ1
Isotype: IgG
Purity: Affinity purification
 
ul:
  • GB11899
  • Servicebio

Description

Product Information


Description

AMPK beta 1 rabbit polyclonal

Protein full name

5'-AMP-activated protein kinase subunit beta-1

Synonyms

Prkab1, PRKAB1, AMPK, HAMPKb, Protein kinase AMP-activated non-catalytic subunit beta 1, AMPKβ1

Immunogen

Recombinant protein corresponding to Mouse AMPKβ1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

Q9Y478, Q9R078, P80386




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human, Mouse, Rat

1: 500-1: 1500

kidney cancer, brain

IF

Human, Mouse, Rat

1: 250-1: 500

kidney cancer, brain




Background


5'-AMP-activated protein kinase subunit beta-1 is an enzyme encoded by the PRKAB1 gene. The protein is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex.




Images


Immunohistochemistry analysis of paraffin-embedded mouse tumor using

AMPKβ1 (GB11899) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded mouse brain using

AMPKβ1 (GB11899) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded rat brain using

AMPKβ1 (GB11899) at dilution of 1: 1000





Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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