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GB11904 Anti -NLK Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse NLK
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11904
  • Servicebio

Description

Product Information


Description

NLK rabbit polyclonal

Protein full name

Serine/threonine-protein kinase NLK

Synonyms

Nlk, NLK, nemo like kinase

Immunogen

Recombinant protein corresponding to

Mouse NLK

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Uniprot ID

O54949, D3ZSZ3




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 500-1: 1500

brain, heart, spinal cord

IF

Mouse, Rat

1: 250-1: 500

brain, heart, spinal cord




Background


Role in cell fate determination, required for differentiation of bone marrow stromal cells. Acts downstream of MAP3K7 and HIPK2 to negatively regulate the canonical Wnt/beta-catenin signaling pathway and the phosphorylation and destruction of the MYB transcription factor. May suppress a wide range of transcription factors by phosphorylation of the coactivator, CREBBP (By similarity). Involved in TGFbeta-mediated mesoderm induction, acting downstream of MAP3K7/TAK1 to phosphorylate STAT3.




Images


Immunohistochemistry analysis of paraffin-embedded mouse brain using

NLK (GB11904) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded rat brain using

NLK (GB11904) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded mouse heart using

NLK (GB11904) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded rat heart using

NLK (GB11904) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded rat spinal cord using

NLK (GB11904) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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