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GB11915 Anti -Telomerase reverse transcriptase Rabbit Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse TERT
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11915
  • Servicebio

Description

Product Information


Description

Telomerase reverse transcriptase

rabbit polyclonal

Protein full name

Telomerase reverse transcriptase

Synonyms

Tert, TERT, CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, Telomerase reverse transcriptase

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse TERT

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

Q673L6




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 1000-1: 2000

lung, heart

IF

Rat

1: 500-1: 1000

lung, heart




Background


Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.




Images


Immunohistochemistry analysis of paraffin-embedded rat lung using

TERT (GB11915) at dilution of 1: 1500

Immunohistochemistry analysis of paraffin-embedded rat heart using

TERT (GB11915) at dilution of 1: 1500




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025

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