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GB11918 Anti -BRCA2 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse BRCA2
Isotype: IgG
Purity: Affinity purification
 
ul:
  • GB11918
  • Servicebio

Description

Product Information


Description

BRCA2 rabbit polyclonal

Protein full name

Breast cancer type 2 susceptibility protein homolog

Synonyms

Brca2, BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, Breast cancer 2, DNA repair associated, breast cancer 2, Early onset, BRCA2 DNA repair associated

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse BRCA2

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

P51587




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Human

1: 1000-1: 2000

tonsil, lung cancer,

ovarian cancer

IF

Human

1: 500-1: 1000

tonsil, lung cancer,

ovarian cancer




Background


Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. May participate in S phase checkpoint activation. Binds selectively to ssDNA, and to ssDNA in tailed duplexes and replication fork structures.




Images


Immunohistochemistry analysis of paraffin-embedded human tonsil using

BRCA2 (GB11918) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded human lung cancer using

BRCA2 (GB11918) at dilution of 1: 1000


Immunohistochemistry analysis of paraffin-embedded human ovarian cancer using BRCA2 (GB11918) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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