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GB11922 Anti -MNK2 Rabbit Polyclonal Antibody

Immunogen: Recombinant protein corresponding to Mouse MNK2
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11922
  • Servicebio

Description

Product Information



Description

MNK2 rabbit polyclonal

Protein full name

MAP kinase-interacting serine/threonine-protein kinase 2

Synonyms

Mknk2, MKNK2, GPRK7, MNK2, MAP kinase interacting serine/threonine kinase 2

Immunogen

Recombinant protein corresponding to Mouse MNK2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

52 kDa

Observed MW.

52 kDa

Uniprot ID

Q9HBH9




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

MCF7, SKBR3




Background


MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme encoded by the MKNK2 gene, which is  a member of the calcium/calmodulin-dependent protein kinases (CAMK) Ser/Thr protein kinase family, belonging to the protein kinase superfamily. This protein is one of the downstream kinases activated by mitogen-activated protein (MAP) kinases. It phosphorylates the eukaryotic initiation factor 4E (eIF4E), thus playing important roles in the initiation of mRNA translation, oncogenic transformation and malignant cell proliferation. In addition to eIF4E, this protein also interacts with von Hippel-Lindau tumor suppressor (VHL), ring-box 1 (Rbx1) and Cullin2 (Cul2), which are all components of the CBC(VHL) ubiquitin ligase E3 complex. Multiple alternatively spliced transcript variants have been found, but the full-length nature and biological activity of only two variants are determined.




Images



image.png

Western blot analysis of MNK2

(GB11922) at dilution of 1: 1000

Lane 1: MCF7 cell lysate

Lane 2: SKBR3 cell lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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