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GB11923 Anti -IKK alpha Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Mouse IKKα
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11923
  • Servicebio

Description

Product Information



Description

IKK alpha rabbit polyclonal

Protein full name

Inhibitor of nuclear factor kappa-B kinase subunit alpha

Synonyms

Chuk, CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16, Conserved helix-loop-helix ubiquitous kinase, Component of inhibitor of nuclear factor kappa B kinase complex

Immunogen

Recombinant protein corresponding to Mouse IKKα

Isotype

IgG

Purity

Affinity purification

Predicted MW.

85 kDa

Observed MW.

85 kDa

Uniprot ID

O15111, Q60680




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

thymus, testis




Background


Acts as part of the IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-kappa-B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-kappa-B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines.




Images



image.png

Western blot analysis of IKKα

(GB11923) at dilution of 1: 1000

Lane 1: HeLa cell lysate

Lane 2: HepG2 cell lysate

Lane 3: HT29 cell lysate

Lane 4: NIH/3T3 cell lysate

Lane 5: Mouse thymus tissue lysate

Lane 6: Mouse testis tissue lysate

Lane 7: Rat thymus tissue lysate

Lane 8: Rat testis tissue lysate




Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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