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GB11939 Anti -MCK10/NEP Rabbit pAb Antibody

Immunogen: Recombinant protein corresponding to Human MCK10
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11939
  • Servicebio

Description

Product Information


Description

MCK10 rabbit polyclonal

Protein full name

Epithelial discoidin domain-containing receptor 1

Synonyms

DDR1, CAK, CD167, DDR, EHGK2, MCK10, NEP, NTRK4, PTK3, PTK3A, RTK6, TRKE, discoidin domain receptor tyrosine kinase 1

Immunogen

Recombinant protein corresponding to Human MCK10

Isotype

IgG

Purity

Affinity purification

Predicted MW.

101 kDa

Observed MW.

120 kDa

Uniprot ID

Q08345




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

SW480, MCF7,

A549, T47-D, A431




Background


Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion.




Images


image.png

Western blot analysis of MCK10 (GB11939) at dilution of 1: 1000

Lane 1: SW480 cell lysate

Lane 2: MCF7 cell lysate

Lane 3: A549 cell lysate

Lane 4: T47-D cell lysate

Lane 5: A431 cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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