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GB11943 Anti -Perforin Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Human Perforin
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11943
  • Servicebio

Description

Product Information


Description

Perforin rabbit polyclonal

Protein full name

Perforin-1

Synonyms

P1, Cytolysin, Lymphocyte pore-forming protein, PFP, PRF1, FLH2, HPLH2, MGC65093, Perforin 1, Perforin 1 precursor, Perforin 1 preforming protein, PGFL, PIGF, PIGF-2, PLGF, SHGC-10760

Immunogen

KLH conjugated Synthetic peptide corresponding to Human Perforin

Isotype

IgG

Purity

Affinity purification

Predicted MW.

61 kDa

Observed MW.

70 kDa

Uniprot ID

P14222, P35763




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Rat

1: 500-1: 1000

thymus, spleen, lung




Background


Perforin 1 is one of the major cytolytic proteins of cytolytic granules. It is known to be a crucial effector molecule in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. This protein has structural and functional similarities to complement component C9. Like C9, this protein creates transmembrane tubules and is capable of lysing nonspecifically a variety of target cells. Defects in PRF1 are the cause of familial hemophagocytic lymphohistiocytosis type 2 (FHL2), a rare and lethal autosomal recessive disorder of early childhood,which is characterized by immune dysregulation with hypercytokinemia and defective natural killer cell function.  Alternative splicing results in multiple transcript variants encoding the same protein.




Images


image.png

Western blot analysis of Perforin (GB11943) at dilution of 1: 800

Lane 1: Jurkat cell lysate

Lane 2: THP-1 cell lysate

Lane 3: SW480 cell lysate

Lane 4: Mouse thymus tissue lysate

Lane 5: Rat spleen tissue lysate

Lane 7: Rat lung tissue lysate

Lane 8: Rat thymus tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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