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GB11945 Anti -ADAM15 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse ADAM15
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11945
  • Servicebio

Description

Product Information


Description

ADAM15 rabbit polyclonal

Protein full name

Disintegrin and metalloproteinase domain-containing protein 15

Synonyms

ADAM15, MDC15,

ADAM metallopeptidase domain 15

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse ADAM15

Isotype

IgG

Purity

Affinity purification

Predicted MW.

93 kDa

Observed MW.

93 kDa

Uniprot ID

Q13444, O88839, Q9QYV0




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

brain, lung, heart




Background


ADAM15 belongs to a family of transmembrane proteins that contain disintegrin and metalloprotease domains. Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain




Images


image.png

Western blot analysis of ADAM15 (GB11945) at dilution of 1: 1000

Lane 1: PC3 cell lysate

Lane 2: Mouse brain tissue lysate

Lane 3: Mouse lung tissue lysate

Lane 4: Rat heart tissue lysate

Lane 5: Rat lung tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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