PHONE

+86(027) 5111 3188

Share to:

GB11950 Anti -Annexin-7/ANXA7 Rabbit pAb Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Annexin-7
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11950
  • Servicebio

Description

Product Information


Description

Annexin-7 rabbit polyclonal

Protein full name

Annexin A7

Synonyms

Annexin VII, Annexin-7, Synexin, Anxa7, Anx7, AnnexinVII, SNX

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Annexin-7

Isotype

IgG

Purity

Affinity purification

Predicted MW.

50 kDa

Observed MW.

50 kDa

Uniprot ID

P20073, Q07076, Q6IRJ7




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

heart, lung




Background


ANXA7 is a member of the annexin family of calcium/phospholipid-binding proteins, and is involved in the process of membrane fusion and exocytosis . Annexin A7 is a GTPase, and both GTPbinding and PKC activity are important in regulating protein function . Membrane binding of annexin A7 is calcium dependent . Two isoforms exist due to alternative splicing. Subcellular localization of annexin A7 has been shown to be in the cytoplasm, vesicular structures, membrane and in adrenal chromaffin granules . Nuclear localization has been shown in the developing mouse central nervous system as well as in adult mouse brain . Annexin A7- deficient mouse studies show that the protein has a role in insulin secretion and calcium signaling as well as cardiac intracellular calcium homeostasis electrical stability . The gene for annexin A7 is a putative tumor suppressor , and alterations in the copy number have been reported in prostate cancer . Annexin A7 expression has alsobeen correlated with survival in human glioblastoma patients , and haploinsufficiency in mice may promote genetic instability leading to tumorigenesis .




Images


image.png

Western blot analysis of Annexin-7 (GB11950) at dilution of 1: 1000

Lane 1: U87 cell lysate

Lane 2: PC3 cell lysate

Lane 3: NIH/3t3 cell lysate

Lane 4: PC12 cell lysate

Lane 5: Mouse heart tissue lysate

Lane 6: Mouse lung tissue lysate

Lane 7: Rat heart tissue lysate

Lane 8: Rat lung tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

Contact us

Quick Links

Product Category

Get In Touch

 5th Floor, 22 Building, Biopark, Gaoxin 2nd Road No. 388, East Lake High-Tech Developing Zone, Wuhan, Hubei, China 430079
 +86(027) 5111 3188
Copyright © 2021  Wuhan Servicebio Technology Co., Ltd.