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GB11957 Anti -Thioredoxin / TRX Rabbit Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Thioredoxin
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11957
  • Servicebio

Description

Product Information


Description

Thioredoxin rabbit polyclonal

Protein full name

Thioredoxin

Synonyms

TXN, TRDX, TRX, TRX1, Thioredoxin

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse Thioredoxin

Isotype

IgG

Purity

Affinity purification

Predicted MW.

12 kDa

Observed MW.

12 kDa

Uniprot ID

P10599, P10639, P11232




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

colon, kidney, liver




Background


Thioredoxins (Trx) are small, multi-functional proteins with oxidoreductase activity and are ubiquitous in essentially all living cells. Trx contains a redox-active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The two cystein residues in the conserved active centers can be oxidized to form intramolecular disulfide bonds. Reduction of the active site disulfide in oxidized Trx is catalyzed by Trx reductase with NADPH as the electron donor. The reduced Trx is a hydrogen donor for ribonucleotide reductase, the essential enzyme for DNA synthesis, and a potent general protein disulfide reductase with numerous functions in growth and redox regulations. Specific protein disulfide targets for reduction by Trx include protein disulfide-isomerase (PDI) and a number of transcription factors such as p53 , NF-kB and AP-1 (T1-151). Trx is also capable of removing H2O2, particularly when it is coupled with either methionine sulfoxide reductase or several isoforms of peroxiredoxins.




Images


image.png

Western blot analysis of Thioredoxin (GB11957) at dilution of 1: 1000

Lane 1: MCF7 cell lysate

Lane 2: Mouse colon tissue lysate

Lane 3: Mouse kidney tissue lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Rat colon tissue lysate

Lane 6: Rat kidney tissue lysate

Lane 7: Rat liver tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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