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GB11958 Anti -uPA Rabbit Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse uPA
Isotype: IgG
Purity: Affinity purification
 
ul:
  • GB11958
  • Servicebio

Description

Product Information


Description

uPA rabbit polyclonal

Protein full name

Urokinase-type plasminogen activator

Synonyms

U-plasminogen activator, Plau, ATF, URK, uPA, Urinary, Urokinase

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse uPA

Isotype

IgG

Purity

Affinity purification

Predicted MW.

48 kDa

Observed MW.

48 kDa

Uniprot ID

P00749, P06869




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse

1: 500-1: 1000

prostate




Background


PLAU, a member of the peptidase family S1, is a potent plasminogen activator and is clinically used for therapy of thrombolytic disorders.

PLAU specifically cleaves the Arg-|-Val bond in plasminogen to form plasmin uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium . The protein is found in high and low molecular mass forms. The single chain molecule is processed into a disulfide-linked two-chain molecule.Each consists of two chains, A and B. The high molecular mass form contains a long chain A. Cleavage occurs after residue 155 in the low molecular mass form to yield a short A1 chain. The protein is used in Pulmonary Embolism (PE) to initiates fibrinolysis. Structurally, PLAU contains 1 EGF-like domain and 1 kringle domain.




Images


image.png

Western blot analysis of uPA (GB11958) at dilution of 1: 1000

Lane 1: PC3 cell lysate

Lane 2: LNCAP cell lysate

Lane 3: Mouse prostate tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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