PHONE

+86(027) 5111 3188

Share to:

GB11959 Anti -Caldesmon/CDM Rabbit Polyclonal Primary Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Human Caldesmon
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11959
  • Servicebio

Description

Product Information


Description

Caldesmon rabbit polyclonal

Protein full name

Non-muscle caldesmon

Synonyms

CDM, L-caldesmon, Cald1, CAD, CALD1, Caldesmon 1, H CAD, LCAD, NAG22, Caldesmon 1 Isoform 1

Immunogen

KLH conjugated Synthetic peptide corresponding to Human Caldesmon

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm

Uniprot ID

Q62736




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Rat

1: 2000-1: 4000

uterus

IF

Rat

1: 1000-1: 2000

uterus




Background


This gene encodes a calmodulin and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids.Binding of caldesmon to actin is weakened by phosphorylation and by calmodulin in the presence of calcium. Caldesmon-1 is encoded by a single gene, which is spliced to generate a widely distributed low molecular weight form and a smooth muscle specific high molecular weight form. Caldesmon-1 is phosphorylated by the cyclin dependent kinase cdc2 and Erk1/2 MAP kinase, both of which prevent the activity of caldesmon-1. Phosphorylation of caldesmon by cdc2 is required for passage of cells through mitosis.Phosphorylation by Erk1/2 is important in regulating smooth muscle contraction .




Images


image.png

Immunohistochemistry analysis of paraffin-embedded rat uterus using Caldesmon (GB11959) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

Contact us

Quick Links

Product Category

Get In Touch

 5th Floor, 22 Building, Biopark, Gaoxin 2nd Road No. 388, East Lake High-Tech Developing Zone, Wuhan, Hubei, China 430079
 +86(027) 5111 3188
Copyright © 2021  Wuhan Servicebio Technology Co., Ltd.