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Anti -Claudin 2 Rabbit PAb for Western Blot

Specification: 100uL
  • GB11972
  • Servicebio
  • Servicebio

Description

Product Information


Description

Claudin-2 rabbit polyclonal

Protein full name

Claudin-2

Synonyms

Cldn2, Claudin-2, SP82, CLD2,

Immunogen

KLH conjugated Synthetic peptide

corresponding to Mouse Claudin-2

Isotype

IgG

Purity

Affinity purification

Predicted MW.

25 kDa

Observed MW.

25 kDa

Uniprot ID

P57739, O88552, D4A386




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

colon, kidney,

small intestine,




Background


The claudin super family consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-2, also known as CLDN2 or SP82, is a 230 amino acid multi-pass membrane protein that localizes to the cell junctions and belongs to the claudin super family. Able to form homopolymers of heteropolymers with other claudin family members, claudin-2 plays an essential role in mediating calcium-independent cell-adhesion activity that is necessary for tight junction-specific obliteration of the intercellular space. Overexpression of claudin-2 is associated with a variety of diseases, including lung cancer, colorectal cancer, gastrointestinal carcinomas and inflammatory bowel disease, further affirming the importance of claudin-2 in cell adhesion. The gene encoding claudin-2 maps to human chromosome X, which contains nearly 153 million base pairs and houses over 1,000 genes.




Images


image.png

Western blot analysis of Claudin-2 (GB11972) at dilution of 1: 1000

Lane 1: Mouse colon tissue lysate

Lane 2: Mouse small intestine tissue lysate

Lane 3: Mouse kidney tissue lysate

Lane 4: Rat small intestine tissue lysate

Lane 5: Rat kidney tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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