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GB11974 Anti -Rad50 Rabbit Polyclonal Primary Antibody

Immunogen: Recombinant protein corresponding to Mouse Rad50
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11974
  • Servicebio

Description

Product Information


Description

Rad50 rabbit polyclonal

Protein full name

DNA repair protein RAD50

Synonyms

mRad50, NBSLD, RAD502, hRad50, Mrell, hsRAD50, RAD50 homolog (S cerevisiae), RAD50 PEN, Rad50l, Truncated RAD50 protein

Immunogen

Recombinant protein corresponding to Mouse Rad50

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

P70388, Q9JIL8




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 500-1: 1500

lung, testis

IF

Mouse, Rat

1: 250-1: 500

lung, testis




Background



The protein encoded by this gene is highly similar to Saccharomyces

cerevisiae Rad50, a protein involved in DNA double-strand break repair. This protein forms a complex with MRE11 and NBS1. The protein complex binds to DNA and displays numerous enzymatic activities that are required for nonhomologous joining of DNA ends. This protein, cooperating with its partners, is important for DNA double-strand break repair, cell cycle checkpoint activation, telomere maintenance, and meiotic recombination. Knockout studies of the mouse homolog suggest this gene is essential for cell growth and viability. Mutations in this gene are the cause of Nijmegen breakage syndrome-like disorder.Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.




Images


image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using Rad50 (GB11974) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat lung using Rad50 (GB11974) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat testis using Rad50 (GB11974) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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