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GB11975 Anti -ATIC Rabbit Polyclonal Antibody

Immunogen: Recombinant protein corresponding to Mouse ATIC
Isotype: IgG
Purity: Affinity purification
ul:
  • GB11975
  • Servicebio

Description

Product Information


Description

ATIC rabbit polyclonal

Protein full name

Bifunctional purine biosynthesis protein PURH

Synonyms

Phosphoribosylaminoimidazolecarboxamide formyltransferase, AICAR transformylase, Atic, Purh, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, Inosinicase

Immunogen

Recombinant protein corresponding to Mouse ATIC

Isotype

IgG

Purity

Affinity purification

Predicted MW.

64 kDa

Observed MW.

64 kDa

Uniprot ID

P31939, Q9CWJ9, O35567




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

HeLa, HepG2, NIH/3T3, PC12, Jurkat




Background


The bifunctional purine biosynthesis protein ATIC (also designated PURH) contains AICAR transformylase and IMP cyclohydrolase activities. AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) transformylase catalyzes the second to last step in purine biosynthesis, playing an important role in the production of nucleotides and IMP. Defects in the ATIC transformylase gene can cause AICA-rebsuria, also designated AICA-ribosiduria, an inborn error in purine biosynthes is that is neurologically cataclysmic. Individuals with AICA-rebosuria accumulate AICA-riboside, also designated ZMP, and its derivatives in erythrocytes and fibroblasts. Patients also excrete very large amounts of AICA-riboside in the urine. Mental retardation, epilepsy, dysmorphic features and congenital blindness are all symptoms of this disease.




Images


image.png

Western blot analysis of ATIC (GB11975) at dilution of 1: 1000

Lane 1: Hela cell lysate

Lane 2: HepG2 cell lysate

Lane 3: NIH/3T3 cell lysate

Lane 4: PC12 cell lysate

Lane 5: Jurkat cell lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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