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Anti -epithelial Sodium Channel Alpha Rabbit PAb For Western Blot

Specification: 100uL
  • GB11977
  • Servicebio
  • Servicebio

Description

Product Information


Description

epithelial Sodium Channel alpha rabbit polyclonal

Protein full name

Amiloride-sensitive sodium channel subunit alpha

Synonyms

Alpha-NaCH, Epithelial Na(+) channel subunit alpha, Alpha-ENaC, Nonvoltage-gated sodium channel 1 subunit alpha, SCNEA, Scnn1a, enac

Immunogen

Recombinant protein corresponding to Mouse enac

Isotype

IgG

Purity

Affinity purification

Predicted MW.

79 kDa

Observed MW.

90 kDa

Uniprot ID

Q61180, P37089




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

liver, lymph grand




Background



Epithelial sodium channels are amiloride-sensitive members of the degenerin/epithelial sodium channel (Deg/ENaC) superfamily of ion channels. Members of this superfamily of ion channels share organizational similarity in that they all possess two short intracellular amino and carboxyl termini, two short membrane spanning segments, and a large extracellular loop with a conserved cysteine-rich region. There are three homologous isoforms of the ENaC (α, β, γ) protein. ENaC in the kidney, lung, and colon plays an essential role in trans-epithelial sodium and fluid balance. ENaC also mediates aldosterone-dependent sodium reabsorption in the distal nephron of the kidney, thus regulating blood pressure. ENaC is thought to be regulated, in part, through association with the cystic fibrosis transmembrane conductance regulator chloride ion channel. Gain-of-function mutations in beta- or gamma-ENaC can cause severe arterial hypertension and loss-of-function mutations in alpha- or beta-ENaC causes pseudohypoaldosteronism.




Images


image.png

Western blot analysis of enac (GB11977) at dilution of 1: 1000

Lane 1: Raji cell lysate

Lane 2: K562 cell lysate

Lane 3: U251 cell lysate

Lane 4: Mouse liver tissue lysate

Lane 5: Mouse lymph gland tissue lysate

Lane 6: Rat liver tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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