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Anti -Bub1 Rabbit pAb for IHC IF

Specification: 100uL
  • GB11979
  • Servicebio
  • Servicebio

Description

Product Information


Description

Bub1 rabbit polyclonal

Protein full name

Mitotic checkpoint serine/threonine-protein kinase BUB1

Synonyms

BUB1, BUB1A, BUB1L, hBUB1 mitotic checkpoint serine/threonine kinase, Budding uninhibited by benzimidazoles 1 homolog

Immunogen

Recombinant protein corresponding to Mouse Bub1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus

Uniprot ID

O08901




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 2000-1: 4000

spleen, lung, testis

IF

Mouse, Rat

1: 1000-1: 2000

spleen, lung, testis




Background


Bub1 was initially identified as the mammalian homolog to the yeast protein through a cDNA screen. Bub1 encodes a serine/threonine-protein kinase involved in the formation of the spindle checkpoint, an important mechanism that ensures high fidelity mitotic chromosome segregation. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants.




Images


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Immunohistochemistry analysis of paraffin-embedded mouse spleen using Bub1 (GB11979) at dilution of 1: 2000

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Immunohistochemistry analysis of paraffin-embedded rat lung using Bub1 (GB11979) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded rat testis using Bub1 (GB11979) at dilution of 1: 4000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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