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Anti -Sprouty 4/Spry-4 Rabbit PAb for Western Blot

Specification: 100uL
  • GB11980
  • Servicebio
  • Servicebio

Description

Product Information


Description

Spry-4 rabbit polyclonal

Protein full name

Protein sprouty homolog 4

Synonyms

Sprouty homolog 4 (Drosophila), HH17, Sprouty homolog 4, SPRY4, sprouty RTK signaling antagonist 4

Immunogen

Recombinant protein corresponding to

Mouse Spry-4

Isotype

IgG

Purity

Affinity purification

Predicted MW.

33 kDa

Observed MW.

35 kDa

Uniprot ID

Q9WTP2




Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1: 500-1: 1000

liver, kidney, brain




Background


This gene encodes a member of a family of cysteine- and proline-rich proteins,also named as Protein sprouty homolog 4, which contains one SPR (sprouty) domain and belongs to the sprouty family. SPRY4 Suppresses the insulin receptor and EGFR-transduced MAPK signaling pathway, but does not inhibit MAPK activation by a constitutively active mutant Ras. Activity of this protein probably impairs the formation of active GTP-RAS. SPRY4 has a cellular function to regulate the actin cytoskeleton, independent of its inhibitory activity on the Ras/MAP kinase signalling. SPRY4, SPRY1, SPRY2, SPRY3 are central and complex regulators of the receptor tyrosine kinase (RTK) signalling pathway.Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants.




Images


image.png

Western blot analysis of Spry-4 (GB11980) at dilution of 1: 1000

Lane 1: Mouse liver tissue lysate

Lane 2: Mouse kidney tissue lysate

Lane 3: Mouse brain tissue lysate

Lane 4: Rat liver tissue lysate

Lane 5: Rat kidney tissue lysate

Lane 6: Rat brain tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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