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Rabbit PAb for Western Blot

Specification: 100uL
  • GB11983
  • Servicebio
  • Servicebio

Description

Product Information


Description

SGK3 rabbit polyclonal

Protein full name

Serine/threonine-protein kinase Sgk3

Synonyms

Cytokine-independent survival kinase, SGK2,  Serum/glucocorticoid-regulated kinase 3, Sgkl, Serum/glucocorticoid-regulated kinase-like, Serine/threonine protein kinase Sgk3, Cisk

Immunogen

Recombinant protein corresponding to Mouse SGK3

Isotype

IgG

Purity

Affinity purification

Predicted MW.

57 kDa

Observed MW.

57 kDa

Uniprot ID

Q96BR1, Q9ERE3, Q8R4V0




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500- 1: 1000

pancreas, liver




Background


Serine/threonine-protein kinase Sgk3 (SGK3), belongs to the Ser/Thr protein kinase family of proteins. The serum- and glucocorticoid-regulated kinase proteins are closely related to the Akt protein family. SGK1, a homolog of SGK3, activates ion channels, in particular potassium (K+) channels. SGK2 and SGK3 have been found to also be involved in this activation process, making all three of these proteins important regulators for cell proliferation, epithelial transport and neuromuscular excitability. SGK3 acts as a mediator of IL-3 dependent survival signals in the cell. It localizes to the early endosome and in vesicle-like structures. SGK3 is a widely expressed protein, but it is primarily detected in kidney, liver, pancreas, brain and heart. Phosphorylation of SGK3 at residue Ser 486 leads to an increase in SGK3 activation.




Images


image.png

Western blot analysis of SGK3 (GB11983) at dilution of 1: 1000

Lane 1: MCF7 cell lysate

Lane 2: HepG2 cell lysate

Lane 3: Hela cell lysate

Lane 4: Mouse pancreas tissue lysate

Lane 5: Mouse liver tissue lysate

Lane 6: Rat pancreas tissue lysate

Lane 7: Rat liver tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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