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Anti -Ataxin 1 Rabbit pAb for WB IHC IF

Specification: 100uL
  • GB11988
  • Servicebio
  • Servicebio

Description

Product Information


Description

Ataxin 1 rabbit polyclonal

Protein full name

Ataxin-1

Synonyms

Spinocerebellar ataxia type 1 protein homolog, Atxn1, Sca1, SCA1D6S504E

Immunogen

Recombinant protein corresponding to Mouse Ataxin 1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Predicted MW.

84 kDa

Observed MW.

100 kDa

Uniprot ID

P54254, Q63540




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human

1: 500-1: 1000

SH-SY5Y, U87, U251

IHC

Mouse, Rat

1: 500-1: 1500

lung, brain

IF

Mouse, Rat

1: 250-1: 1000

lung, brain




Background


Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) ; also known as olivopontocerebellar atrophy I(OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I(ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.




Images


image.png

Western blot analysis of Ataxin 1 (GB11988) at dilution of 1: 1000

Lane 1: SH-SY5Y cell lysate

Lane 2: U87 cell lysate

Lane 3: U251 cell lysate

image.png

Immunohistochemistry analysis of paraffin-embedded mouse lung using Ataxin 1 (GB11988) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat lung using Ataxin 1 (GB11988) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded suckling mice brain using Ataxin 1 (GB11988) at dilution of 1: 1000

image.png

Immunohistochemistry analysis of paraffin-embedded rat brain using Ataxin 1 (GB11988) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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