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Anti -LIMK1 Rabbit PAb for IHC IF Polyclonal Antibody

Specification: 100uL
  • GB11994
  • Servicebio
  • Servicebio

Description

Product Information


Description

LIMK1 rabbit polyclonal

Protein full name

LIM domain kinase 1

Synonyms

LIMK1, KIZ-1, LIM motif-containing protein kinase

Immunogen

Recombinant protein corresponding to

Mouse LIMK1

Isotype

IgG

Purity

Affinity purification

Subcellular location

Cytoplasm, Nucleus

Uniprot ID

P53668, P53669




Applications


Applications

Species

Dilution

Positive Tissue

IHC

Mouse, Rat

1: 1500-1: 3000

lung, brain, spinal cord

IF

Mouse, Rat

1: 750-1: 1500

lung, brain, spinal cord




Background


LIMK1, a member of the Ser/Thr protein kinase family, may be a component of an intracellular signaling pathway and may be involved in brain development. It phosphorylates and inactivates the actin binding/depolymerizing factor cofilin and induces actin cytoskeletal changes. The LIM domain interacts with the cytoplasmic domain of NRG1, and this cytoplasmic protein also binds ROCK1, which phosphorylates LIMK1 on serine and/or threonine residues. Highest expression occurs in both adult and fetal nervous systems. It is detected ubiquitously throughout the different regions of adult brain, with highest levels in the cerebral cortex, and is expressed to a lesser extent in heart and skeletal muscle. Haploinsufficiency of LIMK1 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in Williams-Beuren syndrome (WBS), a rare developmental disorder.




Images


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Immunohistochemistry analysis of paraffin-embedded mouse lung using LIMK1 (GB11994) at dilution of 1: 2000

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Immunohistochemistry analysis of paraffin-embedded rat lung using LIMK1 (GB11994) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded mouse brain using LIMK1 (GB11994) at dilution of 1: 2000

image.png

Immunohistochemistry analysis of paraffin-embedded rat spinal cord using LIMK1 (GB11994) at dilution of 1: 2000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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