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Anti -H Cadherin Rabbit PAb for Western CRO Polyclonal Antibody

Specification: 100uL
  • GB11996
  • Servicebio
  • Servicebio

Description

Product Information


Description

H Cadherin rabbit polyclonal

Protein full name

Cadherin-13

Synonyms

Heart cadherin, Truncated cadherin, T-cad, T-cadherin, CDH13, CDHH, P105

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse H Cadherin

Isotype

IgG

Purity

Affinity purification

Predicted MW.

78 kDa

Observed MW.

78 kDa

Uniprot ID

P55290, Q9WTR5, Q8R490




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500- 1: 1000

NIH/3T3, cortex,

spinal cord, heart




Background


Cadherin13 is a member of the cadherin family of transmembrane glycoproteins that mediate calcium-dependent intercellular adhesion. However, Cadherin13 is an atypical member, lacking transmembrane and cytosolic domains and containing a GPI moiety that anchors Cadherin13 to the plasma membrane . Human Cadherin13 is synthesized as a 713 amino acid precursor that contains a 22 aa signal sequence, a 116aa propeptide, a 555aa mature chain, and a second propeptide of 20aa that is removed in the mature form to reveal the GPI anchor. The mature form contains five cadherin domains and eight potential sites for N-linked glycosylation. The structural characteristics of Cadherin13 predict that it is unlikely to function as a true adhesion molecule in vivo . It is suggested that it may act rather as a signaling receptor participating in recognition of the environment and regulation of cell motility, proliferation, and phenotype .Cellular expression levels of Cadherin13 in various tissues often correlate, negatively or positively, with the proliferative potential of the cells . Cadherin13 may also act as a suppressor of tumor cell growth .



Images


image.png

Western blot analysis of H Cadherin (GB11996) at dilution of 1: 1000

Lane 1: NIH/3T3 cell lysate

Lane 2: Mouse cortex tissue lysate

Lane 3: Mouse spinal cord tissue lysate

Lane 4: Mouse heart tissue lysate

Lane 5: Rat Cortex tissue lysate

Lane 6: Rat spinal cord tissue lysate

Lane 7: Rat heart tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE: This product is intended for research only.

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