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GB121043 Anti -Nucleophosmin Rabbit pAb Polyclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse Nucleophosmin
Isotype: IgG
Purity: Affinity purification

 

ul:
  • GB121043
  • Servicebio

Description

Product Information


Description

Nucleophosmin rabbit polyclonal

Protein full name

Nucleophosmin

Synonyms

NPM, Nucleolar phosphoprotein B23, Nucleolar protein NO38, Numatrin, Npm1

Immunogen

KLH conjugated Synthetic peptide corresponding to Mouse Nucleophosmin

Isotype

IgG

Purity

Affinity purification

Subcellular location

Nucleus, Cytoplasm

Predicted MW.

33 kDa

Observed MW.

40 kDa

Uniprot ID

P06748, Q61937, P13084




Applications


Applications

Species

Dilution

Positive Tissue

WB

Human, Mouse, Rat

1: 500-1: 1000

spleen, testis




Background

Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF.
Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1endonuclease activity on apurinic/apyrimidinic double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication.




Images



Western blot analysis of Nucleophosmin (GB121043) at dilution of 1: 1000

Lane 1: Hela cell lysate

Lane 2: HepG2 cell lysate

Lane 3: MCF7 cell lysate

Lane 4: NIH3T3 cell lysate

Lane 5: PC12 cell lysate

Lane 6: Mouse spleen tissue lysate

Lane 7: Mouse testis tissue lysate

Lane 8: Rat spleen tissue lysate

Lane 9: Rat testis tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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