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GB121363 Anti -STAT1 Mouse Monoclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse STAT1
Isotype: IgG
Purity: Affinity purification
ul:
  • GB121363
  • Servicebio

Description

Product Information


Description STAT1 mouse monoclonal
Protein full name Signal transducer and activator of transcription 1
Synonyms CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse STAT1
Isotype IgG
Predicted MW. 87 kDa
Observed MW. 87 kDa
Purity Affinity purification
Uniprot ID P42225, P42224




Applications


Applications Species Dilution Positive Tissue
WB Human, Mouse 1:500-1:1000 spleen, lung, brain




Background

Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state.




Images


Western blot analysis of STAT1 (GB121363
at dilution of 1: 1000
Lane 1: Jurkat cell lysate
Lane 2: MCF7 cell lysate
Lane 3: Raw264.7 cell lysate
Lane 4: Mouse spleen tissue lysate
Lane 5: Mouse lung tissue lysate
Lane 6: Mouse brain tissue lysate




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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