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GB12284 Anti -Hsp90 Mouse Monoclonal Antibody

Immunogen: KLH conjugated Synthetic peptide corresponding to Mouse HSP90A
Isotype: IgG
Purity: Affinity purification
ul:
  • GB12284
  • Servicebio

Description

Product Information


Description HSP90 mouse monoclonal
Protein full name Heat shock protein HSP 90-alphav
Synonyms HSP90AA1, EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2, HEL-S-65p, Heat shock protein 90kDa alpha
Immunogen KLH conjugated Synthetic peptide
corresponding to Mouse HSP90A
Isotype IgG
Subcellular location Nucleus, Cell membrane, Cytoplasm
Predicted MW. 90 kDa
Observed MW. 90 kDa
Purity Affinity purification
Uniprot ID P07900, P82995, P07901




Applications


Applications Species Dilution Positive Ttissue
WB Human, Mouse, Rat 1: 500-1: 1000 brain, testis
IHC Mouse, Rat 1: 500-1: 1000 testis, ovary, brain, colon




Background


Complemented by the constitutively expressed paralog Hsp90B which shares over 85% amino acid sequence identity, Hsp90A expression is initiated when a cell experiences proteotoxic stress. Once expressed Hsp90A dimers operate as molecular chaperones that bind and fold other proteins into their functional 3-dimensional structures. This molecular chaperoning ability of Hsp90A is driven by a cycle of structural rearrangements fueled by ATP hydrolysis. Current research on Hsp90A focuses in its role as a drug target due to its interaction with a large number of tumor promoting proteins and its role in cellular stress adaptation.




Images


Western blot analysis of HSP90 (GB12284)
at dilution of 1: 1000
Lane 1: Hela cell lysate
Lane 2: A431 cell lysate
Lane 3: 293T cell lysate
Lane 4: MCF7 cell lysate
Lane 5: Jurkat cell lysate
Lane 6: Mouse brain tissue lysate
Lane 7: Mouse testis tissue lysate
Lane 8: Rat brain tissue lysate
Lane 9: Rat testis tissue lysate

Immunohistochemistry analysis of paraffin-embedded mouse testis using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat testis using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded mouse ovary using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat ovary using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded mouse brain using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat brain using
HSP90 (GB12284) at dilution of 1: 1000
Immunohistochemistry analysis of paraffin-embedded rat colon using
HSP90 (GB12284) at dilution of 1: 1000




Storage


Storage Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles.
Storage Buffer PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).

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